After graduating from college, McPherson turned professional and competed on the Futures Tour. From 2003 to 2006 she competed in 60 events, never missed a cut, and won twice,. Her fourth place finish on the Futures Tour money list in 2006 earned her an LPGA Tour card for the 2007 season. Her first season on the LPGA brought limited success, with a best finish a tie for 18th; she finished the season 97th on the official LPGA money list. In 2008, her second year, she recorded six top-10 finishes, finishing 47th on the official money list. In 2009, McPherson recorded a T-2 in a LPGA major, the Kraft Nabisco Championship, followed by a T-5 three months later at the next major, the LPGA Championship.